WebbThis study investigated the protective effects of glucocerebroside-containing buttermilk concentrated powder (GCBM) on oxidative stress and photoaging in ultraviolet B (UVB)-irradiated hairless mice. We measured antioxidant enzyme activities, collagen synthesis-related pathways, and moisturizing-related factors in the dorsal skin of mice. We … Webb4 apr. 2024 · Methods and Results: Western blot data showed that APE1 and SMAD3 were highly expressed in EAC cell lines. APE1 silencing reduced SMAD3 nuclear expression and downregulated its downstream targets SERPINE1 and c-myc. These results were confirmed by immunofluorescence staining showing loss of nuclear accumulation of SMAD3 after …
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Webb28 mars 2024 · Smad3 can be activated not only by TGF-β1 but also by many stress molecules including angiotensin II (Ang II), advanced end products (AGEs), and C … Webb3 feb. 2024 · Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are … how to run windows 10 app as administrator
TGF-β信号通路与Smad家族蛋白 纽普生物
Webb10 apr. 2024 · Protein degradation patterns of both high- and low-molecular-weight structural proteins are examined. The complete breakdown of both troponin-T as well as the majority of the 30 kD component occurred at the high pH extreme. Intermediate pH revealed incomplete troponin-T breakdown and this may be related, in part, to its … Webb9 juni 2024 · The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer Zane A Gibbs, Luis C Reza, Chun-Chun Cheng, Jill M Westcott, Kathleen McGlynn, Angelique W Whitehurst Department of Pharmacology, University of Texas Southwestern Medical Center, United States; WebbMagnetic beads from a Magnetic RNA–Protein Pull-Down Kit (Thermo Fisher Scientific; 20164) were utilized to capture RNA–protein complexes. Proteins were eluted from the beads and analyzed by western blotting. CARPID. The CARPID approach was utilized to validate interactions between lncRNAs and proteins of interest at the endogenous level. how to run windirstat