WebPHF21A; see all. Function. Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it ... WebJul 13, 2012 · PHF21A encodes a plant homeodomain finger protein whose murine and zebrafish orthologs are both expressed in a manner consistent with a function in …

Anti-BHC80 / PHF21A antibody (ab224612) Abcam

WebFeb 1, 2024 · PHF21A is genetically associated with Potocki–Shaffer Syndrome, but the molecular basis of cognitive deficits is unknown.. RNA-Seq of PHF21A-deficient patient cells revealed 1,885 commonly misregulated genes.. Pathway analysis showed downregulation of pathways relevant to learning and memory, including cAMP-mediated signaling. • Reporter … microsoft word table row height

Disruption of PHF21A causes syndromic intellectual disability with …

WebDec 17, 2024 · PHF21A (PHD finger protein 21A) gene, located in the short arm of chromosome 11, encodes for BHC80, a component of the Lysine Specific Demethylase 1, Corepressor of REST (LSD1-CoREST) complex. BHC80 is mainly expressed in the human fetal brain and skeletal muscle and acts as a modulator of several neuronal genes during … WebABCA3 es una proteína de la subfamilia A de las proteínas de unión a ATP (ABC) que se expresa en los neumocitos tipo II del pulmón. Su función principal es participar en la síntesis y transporte del surfactante pulmonar, cuya deficiencia se asocia con enfermedades pulmonares graves en recién nacidos y adultos. WebImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BHC80 / PHF21A antibody (ab224612) Paraffin embedded human adrenal gland tissue stained for … new shoes meyer book