WebDec 20, 2024 · CHAARTED was a phase III, open-label study that randomly assigned 790 patients to receive either androgen-deprivation therapy (ADT) plus six cycles of docetaxel or ADT alone. It revealed a greater than 12-month overall survival benefit to adding docetaxel to ADT compared with ADT alone. WebJul 1, 2024 · A total of 307 (57.7%) patients were defined as having both CHAARTED high-volume and LATITUDE high-risk disease. The median castration-resistant prostate cancer …
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WebApr 10, 2024 · Like the better-known prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) is a biomarker that can tell physicians much about a patient's metastatic prostate cancer. PSMA is ... WebApr 14, 2024 · Based on the CHAARTED study, high volume patients are considered patients with mHSPC with 4 or more bone lesions with 1 of the lesions outside of the actual skeleton. So for instance, if you had a cancer in the femur or the humerus that's considered a high volume based upon the number of bones as long as 1 of the 4 bones is outside of the ... slave breeding plantations
Recent Advances in the Management of Metastatic …
WebMay 31, 2024 · The definition of high-volume disease was adapted from the Chemohormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) 7: visceral... WebApr 12, 2024 · Docetaxel plus ADT should be offered to patients with metastatic noncastrate prostate cancer with high-volume disease (four or more bone metastases, one or more of … WebDec 1, 2024 · The high-volume criteria of the CHAARTED trial meet the presence of visceral metastases or four or more bone lesions with at least one beyond the vertebral bodies … slave broadway