Cytochrome p450-activated prodrugs
WebSep 22, 2024 · Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an important role in the metabolism of endogenous as well as exogenous substances, especially drugs. Moreover, many P450s can serve as targets for disease therapy. Increasing reports of epidemiological, diagnostic, and clinical research indicate that … WebCytochromes P450 activated prodrugs Cytochrome P450 enzymes, frequently expressed in cancer cells, can be utilised as targets for selective bioactivation of duocarmycin bioprecursors. Ongoing projects are focused on prodrug development (funded by a £1.5m Yorkshire Cancer Research programme) and combinations with radiotherapy in breast …
Cytochrome p450-activated prodrugs
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WebAug 1, 2007 · CYP450 enzyme polymorphism is responsible for observed variations in drug response among patients of differing ethnic origins. 4 – 6 For example, 7 percent of white persons and 2 to 7 percent of ... WebJan 30, 2013 · The activation of prodrugs by the cytochrome P450 system provides a highly versatile approach to prodrug design that is particularly adaptable for …
WebMar 1, 2006 · HepDirect prodrugs represent a novel class of cytochrome P450-activated prodrugs capable of targeting certain drugs to the liver. In this review, the HepDirect prodrug concept and its use for the ... WebCytochrome P450 is a family of isozymes responsible for the biotransformation of several drugs. Drug metabolism via the cytochrome P450 system has emerged as an important …
WebJul 21, 2003 · Cytochrome P450-based gene therapy can substantially increase the sensitivity of tumor cells to P450-activated cancer chemotherapeutic prodrugs such as cyclophosphamide (CPA) without … WebZanger UM. Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138(1):103-41. Ortiz deMontellano PR. Cytochrome P450-activated prodrugs. Future Med Chem. 2013;5(2):213-228.
WebApr 1, 2004 · The prodrugs are substituted cyclic 1,3-propanyl esters designed to undergo an oxidative cleavage reaction catalyzed by a cytochrome P(450) (CYP) expressed predominantly in the liver. Reported herein is the discovery of a prodrug series containing an aryl substituent at C4 and its use for the delivery of nucleoside-based drugs to the liver.
WebTitle: Cytochrome P450-Activated Prodrugs: Targeted Drug Delivery Volume: 15 Issue: 23 Author(s): Kristiina M. Huttunen, Niina Mahonen, Hannu Raunio and Jarkko Rautio Affiliation: Keywords: Antibody-directed enzyme prodrug therapy (ADEPT), cyclic phosphate, cytochrome P450 enzyme, gene-directed enzyme prodrug therapy (GDEPT), N-oxide, … pct 92 bis formWebThe result indicated that 1,3‐cyclic propanyl phosphate esters of 18 β‐glycyrrhetic acid have sustained‐release properties to avoid the quick metabolism of 18β‐ glycyRRhetic acid. A new class of potential prodrugs, 1,3‐cyclic propanyl phosphate esters of 18β‐glycyrrhetic acid, was designed and synthesized through the key reaction of 18β‐glycyrrhetic acid … scs ray 10 land cruiserWebFeb 1, 2008 · Cytochromes P450 represent one of the dominant classes of enzymes capable of transforming prodrugs into active drugs (16). However, there are numerous … pct-99rh1a