Cisplatin ld50 in mice
WebSingle dose of cisplatin (16 mg/kg) in aging and young mice resulted in 100% mortality of 24-month-old female mice and 40% mortality of 4-8-week-old mice within 7 days after administration [148, 149]. Increased … WebDec 1, 1987 · Calculated pharmacokinetic parameters (peak concentrations, half-lives, areas under the curve) were compared with the corresponding values in patients at the maximal tolerated dose. Peak plasma concentrations were 2.4- to 20-fold higher in mice than in humans. Initial and terminal half-lives in mice were up to 6 times shorter than in …
Cisplatin ld50 in mice
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WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 3 of 7 Version: 1.1 7. HANDLING AND STORAGE ... Rat Oral LD50 3000 mg/kg Sodium chloride Eye Irritation Rabbit Moderate Mouse Oral LD 50 4000 mg/kg Mouse Oral LD 50 32.7 mg/kg ... WebDec 21, 2024 · Mice were divided into a control group, cisplatin-treated group, and cisplatin + myo-inositol-treated group, which were treated with cisplatin or myo-inositol accordingly. Mice received intraperitoneal injection of cisplatin at a dose of 25 mg/kg, and they were sacrificed by cervical dislocation three days later.
WebThe mice were sacrificed on the 35th day from the first injection. Estimation of Acute Toxicity of Polycisplatin. ICR mice (5 weeks old) weighing 20–23 g were subjected to a study to measure the lethal dose (LD 50) of Polycisplatin to compare with that of cisplatin. The mice were randomly divided into six groups with four mice each. WebAug 14, 2024 · The vehicle control mice were injected with normal saline (cisplatin group) or corn oil (AAI group). After collecting the blood and urine samples from each mouse, the levels of nephrotoxic...
WebThe 50% lethal dose (LD50) of cisplatin in S3 cells was 4 x 10 (-5) M after 20 h incubation and 8.5 x 10 (-6) M after 40 h incubation. Outer medullary collecting duct (OMCD) cells were damaged 30% maximally after 20 h incubation with cisplatin, and LD50 in them became 2.5 x 10 (-5) M after 40 h incubation.
WebDec 23, 2024 · In humans, the volume of peritoneal fluid ranges from 50 to 75 ml ( 7 ), whereas in mice its volume ranges between 0.02 and 0.1 ml ( 8 ). In addition, the peritoneal fluid contains leukocytes and antibodies to fight off infections, and plasma proteins at concentration that is about 50% of what is found in plasma ( 9 ).
WebSep 1, 2024 · The serum of nutlin-3a or cisplatin-treated mice was obtained 4 h after LPS injection. Tissues of nutlin-3a or cisplatin-treated mice were obtained 12 h after LPS injection. Survival of mice was monitored after an i.p. injection of LPS (60 mg/kg) or E. coli (1 × 10 8 CFU). incarnation\u0027s m4WebJun 30, 1983 · The embryonic LD50 for mice was 5.24 mg/kg. An increase in the incidence of growth retardation or gross malformations was not discernable in the surviving fetuses with the number of dams used in this study. Cisplatin is highly embryolethal in rats and mice at dosages well below the adult therapeutic dosage in humans. incarnation\u0027s maWebOct 6, 2014 · Synonyms Cisplatin; cis-DDP Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product use. Details of the supplier of the safety data sheet Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / … in custody lookup lane countyWebAug 6, 2024 · The mice in cisplatin groups were intraperitoneally administered (2 mg/kg cisplatin dissolved in 0.9% saline) with 0.1 ml of cisplatin. The mice in the normal control (NC) group were intraperitoneally injected with physiological saline. The … incarnation\u0027s mhWebApr 13, 2024 · Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex malignant diseases with a high level of heterogeneity and, as a result, a wide range of therapeutic responses ... in custody locatorWebNude mice were divided into 3 groups (etoposide, cisplatin and MTX-group), 7 to 9 per group and received drug treatment which started when their tumor grew to 100 approximately 300 mm3 in volume. All drugs were intraperitoneally administrated to nude mice (each drug: 1/4 mouse LD50 dose X3, weekly). incarnation\u0027s mgWebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … incarnation\u0027s mb