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Cisplatin kidney injury

WebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) which occurs in 20–30% of patients, following a single injection of cisplatin . Even the mechanism of cisplatin-induced acute tubular necrosis ... WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed.

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WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ... WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … bishop transmission dallas https://brazipino.com

Frontiers Protective Effect of Mannitol on Cisplatin-Induced ...

WebApr 8, 2024 · Acute kidney injury (AKI) comprises a group of clinical syndromes characterized by the sudden or continued decrease of renal function as shown by rapidly increased serum creatinine and reduced estimated glomerular filtration rates ( 1 ). AKI usually happens in hospitalized patients with high morbidity and mortality. WebJan 18, 2024 · Background Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI. Methods Japanese patients, who received cisplatin as the first-line chemotherapy at … WebJan 28, 2024 · A major adverse consequence of cisplatin therapy is acute kidney injury (AKI). It is reported that between 30 and 38 percent of patients develop signs of nephrotoxicity (toxicity in the kidneys) after a single cisplatin dose, despite strategies such as hydration to limit renal exposure. This is problematic for patients as kidney injury can ... bishop trains

Cisplatin-Induced Rodent Model of Kidney Injury ... - Hindawi

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Cisplatin kidney injury

Mitofusin2 ameliorated ER stress and mitochondrial ROS …

WebThe prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute … WebThe most direct evidence for NLRP3 involvement in CIN comes from NLRP3-specific inhibitor experiments that showed protection against CIN. Cisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, demonstrating the role of the NLRP3 inflammasome in exacerbating CIN directly .

Cisplatin kidney injury

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WebTY - JOUR. T1 - Caught in the crossfire. T2 - cancer, cisplatin therapy, and kidney injury. AU - Humphreys, Benjamin D. PY - 2024/4/1. Y1 - 2024/4/1 WebNational Center for Biotechnology Information

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). 1. Introduction. Acute kidney injury (AKI) is defined as a clinical syndrome …

WebApr 6, 2015 · Drug-induced AKI, as observed during cisplatin-based anticancer therapy, is responsible for about 20% of renal failure cases. The initial injury triggers a proliferative response in renal tubular cells, which in the presence of cellular damage can further accelerate renal injury.

WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. In this study, IS reduced the expression of Mas receptor ...

WebFeb 3, 2024 · Cisplatin, a widely used anticancer agent, can cause nephrotoxicity, including both acute kidney injury (AKI) and chronic kidney diseases, by accumulating in renal tubular epithelial cells (TECs). Mitochondrial pathology plays an important role in the pathogenesis of AKI. dark spot face creamWebMar 27, 2024 · Cisplatin causes tubular damage and acute kidney injury (AKI) [ 10, 11 ]. Although AKI is a long-term risk factor for chronic kidney disease and death [ 12, 13 ], no clinical studies have examined the association between cisplatin-induced AKI (c-AKI) and postoperative complications. dark spot in center of visionWebWhile the pathogenesis of cisplatin-induced kidney injury is complex, the major underlying mechanisms converge on oxidative stress, inflammation, and renal fibrosis [ 11, 17 ], which may involve major NAD + -dependent redox enzymes, such as mitochondrial complex I, CD38, NNT, NADK, PARP, alpha-keto acid dehydrogenases, and sirtuins. bishop transmission grand rapids mnWebSep 2, 2024 · MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 complex–mediated necroptosis (Kim et al., 2024). Meanwhile, MLT increases the expression of an anti-aging protein, Koltho, and prevents cellular apoptosis, resulting in maintaining the renal ... bishop transmission partsWebFeb 18, 2024 · Decades of research have resulted in significant insight into the pathogenesis of cisplatin-induced AKI, including tubular cell injury and death, vascular damage, oxidative stress, and an... bishop translateWebDec 21, 2024 · Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ]. dark spot face cream removerWebFeb 1, 2024 · Cis-diamminedichloroplatinum (cisplatin) is an effective agent for treating solid tumors. However, its clinical use is limited by its serious toxic side effects; nephrotoxicity is the most common... bishop transport broome