Chondrocyte biology

Author: rqce

August undefined, 2024

WebHuman Chondrocytes, HC, are derived from normal human articular cartilage where they produce and maintain the extracellular matrix of cartilage, including type II collagen. Chondrocytes grown in monolayer culture on a solid surface tend to lose their phenotypic markers and became de-differentiated to a fibroblast-like phenotype. WebJul 31, 2024 · Special Issue Information. The chondrocyte, a mesenchymal progenitor derivative, is the sole cell type found in vertebrate hyaline growth plates and articular cartilage tissues. It is responsible for the development and maintenance of the cartilage extracellular matrix, and responds to both molecular and mechanical cues.

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WebMar 1, 2024 · noun, plural: chondrocytes A cell occupying a lacuna in the extracellular matrix of the cartilage Supplement The cartilage is an animal connective tissue. It … WebMar 3, 2024 · Chondrocytes were exposed to mechanical stress with intensity of 2,000 μstrain at a frequency of 1 Hz for 4 h. For the control group, cells were cultured in the same condition without mechanical stress stimulation for 4 h. RNA Isolation and Real-Time Polymerase Chain Reaction (RT-PCR) command prompt disable hibernation

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WebJan 15, 2024 · SDF-1α, the most common isoform of stromal cell-derived factor 1, has shown vital effects in regulating chondrocyte proliferation, maturation, and chondrogenesis. Autophagy is a highly conserved biological process to help chondrocytes survive in harsh environments. However, the effect of SDF-1α on chondrocyte autophagy is still … WebApr 14, 2024 · The loss of WLS specificity in cartilage resulted in delayed chondrocyte differentiation, disorganized chondrocyte arrangement, and impaired endochondral … command prompt desktop shortcut

TC28a2 Human Chondrocyte Cell Line Millipore - Sigma-Aldrich

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WebJul 24, 2024 · Biology definition: Chondroblasts refer to any of the perichondrial cells involved in the formation of chondrocytes and ECM of the cartilage. Etymology: Greek “khondros” (cartilage) and “blastos” (germ). Synonyms: subchondral cortico-spongious progenitors; perichondrial cells; chondroplast. Figure 2: Chondroblasts of cartilage. WebDec 5, 2024 · The profiled open chromatin regions recapitulate known chondrocyte and skeletal biology, are enriched at height GWAS loci, particularly near differentially expressed growth plate genes, and … command prompt device infoWebNov 9, 2024 · Chondrocyte phenotype maintenance and switch are controlled by an intricate network of intracellular factors, each influenced by a myriad of feedback mechanisms, making it challenging to intuitively predict treatment outcomes, while in silico modeling can help unravel that complexity. command prompt di macbook

"WebMay 28, 2024 · Chondrocytes originate from bone marrow mesenchymal stem cells (BMSCs). First, aggregated BMSCs are capable of differentiating into chondroprogenitor … " - Chondrocyte biology

Chondrocyte biology

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WebJun 11, 2024 · Chondrocyte biology is a hot topic, because osteoarthritis (OA) is a serious problem in an aging society, but there are no fundamental therapeutic drugs. This Special Issue aimed to collect the recent progress in the molecular aspects of chondrocyte proliferation, differentiation, and death and the pathogenesis of OA and rheumatoid … WebNov 15, 2024 · The first detailed nanometer-scale study of the three-dimensional anatomy of a chondrocyte primary cilium was carried out in 1978 [] by exhaustive serial TEM imaging of ultrathin sections.Since then, electron tomography, or imaging biological structures using transmission electron microscopy (TEM) for 3D reconstruction, is widely used [3,19]. ...

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WebThese effects might be secondary to improved OA or due to the regulation of hypertrophic chondrocyte biology in the subchondral bone. Nevertheless, GRGDS treatment had no effect on the subchondral bone plate thickness (PI.Th), subchondral trabecular number (Tb.N), and subchondral trabecular spacing (Tb.Sp) ( Supplementary Figure S7 ). WebChondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage formation and functionality. It arises from mesenchymal stem cells (MSCs) …

WebGeneral description The chondrocyte is the only specialized cell type present in articular cartilage. They produce secretions to support and repair the cartilage matrix. Human chondrocytes in mature articular cartilage are post-mitotic and terminally differentiated cells. WebMechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis Authors Weizhou Jiang 1 , Huan Liu 2 , Rongxue Wan 3 , Yanjiao Wu 4 , Zhanjun Shi 5 , Wenhua Huang 6 Affiliations

WebApr 12, 2024 · Inhibition of condylar chondrocyte ferroptosis could be a promising therapeutic strategy for TMJOA. ### Competing Interest Statement The authors have declared no competing interest. bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution ... WebSep 10, 2024 · Chondrocytes are the cells responsible for cartilage formation, and they are crucial for the process of endochondral ossification, which is useful for bone development. Also, by mimicking skeletal development chondrocytes play a critical role in fracture repair. What is Chondroblast and osteoblast?

WebThe cartilage cells or chondrocytes are contained in cavities in the matrix, called cartilage lacunae; around these, the matrix is arranged in concentric lines as if it had been formed in successive portions around the cartilage cells. This constitutes the so-called capsule of …

WebMechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis. Weizhou Jiang, Huan Liu, Rongxue Wan, Yanjiao Wu, ... Wenhua Huang. Article 101315 View PDF. Article preview. select article Role of the DNAJ/HSP40 family in the pathogenesis of insulin resistance and type 2 diabetes. command prompt disappears after executionWeb15 hours ago · Upon addition of chondrocyte exosomes to a tissue engineering scaffold, they stimulated the formation of regenerated cartilage via the TGF-/SMAD signaling pathway, where SOX-9 and COL-II were ... drying capsules audio novaWebChondrocyte culture is an efficient target system for evaluation of the pharmacological and toxicological effects of drugs acting on cartilaginous tissue. Many types of culture exist and have their own advantages and drawbacks. For example, in monolayer culture … command prompt dir get short file name