WebWe recently demonstrated that the sphingolipid enzyme acid ceramidase (ASAH1) is required for this process. Since specific ASAH1 inhibitors are not clinically available, we … WebSimilarly, a dual SPHK1/2 inhibitor developed by Amgen, “Compound A”, did not inhibit cancer cell proliferation or survival and had no effect as a single agent in a mouse breast cancer xenograft model, ... ASAH1 expression has been positively correlated with Akt phosphorylation in prostate cancer tissues [176,177].
Proteomic Analysis of Quercetin-Treated K562 Cells
WebASAH1 is upregulated in GBM compared to non-tumor. 9 of 13 Carmofur, and the inhibition of ASAH1, decreased in vitro migration of GBM cells and patient-derived xenograft models [91]. Finally,... Web29 mar 2024 · ASAH1 inhibition synergistically sensitizes lung cancer cells resistant to the antiproliferative effect of choline kinase alpha inhibitors. Our results reveal a … husker football ticket office
Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny …
Web1 lug 2024 · ASAH1 is a lysosomal enzyme in the sphingolipid metabolic pathway that hydrolyzes the pro-apoptotic sphingolipid, ceramide, to generate sphingosine. … Web5 set 2024 · Obtained data revealed that ASAH1 was involved in HCT 116 cell response to OXA and that anti-proliferative, pro-apoptotic, anti-migratory and anti-clonogenic effects of OXA could be significantly increased by combination treatment with … Web26 set 2024 · Suppression of ASAH1 by shRNA or the inhibitor ARN14976 (17a) markedly decreased the viability of TSC2-null cells. In vivo, 17a significantly decreased the growth of Tsc2-null cell derived mouse xenografts. husker football stadium seating map